Your liver is the largest organ in your body and part of your digestive system. Your liver is under your diaphragm, next to your stomach and above your right kidney. It is dark reddish brown and divided into the right and left lobes.

Common reasons for transplant

Liver disease occurs when:

  • the liver cells die
  • healthy tissue become scared

Liver transplant

You may need a liver transplant if your liver becomes damaged because of:

As the liver gets progressively damaged it will lose its functions causing liver failure, or end-stage liver disease.

Isolated hepatocytes transplant is also another treatment for acute liver failure and liver diseases involving enzyme deficiencies.


  • getting rid of toxins
  • helping to regulate your blood sugar levels
  • producing bile

Liver facts

  • carry out around 500 different functions
  • can lose 75% of its cells before it stops working
  • a normal liver can regenerate lost tissue – as little as  25% can re-grow to full size
  • Cirrhotic livers do not regenerate normally

Living liver donation

Living donation is when you donate a part of your liver to someone. Living donor liver transplantation has been successfully performed in the UK since 1995.

Further information